A man accused of murdering his wife and co-workers leads the CSIs on a wild chase through a busy Vegas casino.

As the man barricades himself and a hostage in a casino hotel room, the CSIs sift through the overwhelming evidence in order to determine whether the man worked alone or with an accomplice. When time begins to run out, one member of the team puts his life on the line and steps in as hostage negotiator in a last ditch attempt to save an innocent victim.

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