Greg Navarro is arrested for second attempting to assassinate Dennis Ryland. Knowing she is the key to her mothers survival Isabelle attempts to kill herself by jumping off the 4400 center building, only to survive with out scratch. Matthew Ross expresses his displeasure at her actions and tells her of the destiny she is to face. Isabelle is troubled about what Matthew told her, but after a discussion with Shawn she decides its her choice with what she does with her life. Matthew gives Isabelle a substance that can kill her if its injected. In the end Isabel chooses her own life over her mothers. As Lily Tyler passes away, the Nova Group suprises the world by growing a wheat field in the desert which benifits humanity.