Dr.Cox (John C. McGinley) channels TV doctor 'House' to solve three mysteries including; why a man's skin is inexplicably orange, why a young woman, with no coronary issues has a failing heart and why Elliot (Sarah Chalke) is taking her anger towards Dr. Kelso (Ken Jenkins) out on Turk (Donald Faison). But the doctor may be missing the biggest clue of all when Carla (Judy Reyes) begins to show signs of postpartum depression. Meanwhile, J.D. (Zach Braff) tries to be the 'best boyfriend ever' so that Kim (Elizabeth Banks) won't take the job in St. Louis.

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