The team takes on the case of Lupe, a young female scam artist who passes out while working a card-playing scheme on the streets. Lupe suffers from a lack of blood to the brain which had temporarily paralyzed her ability to make decisions or exercise free will. Measuring from her background, Foreman immediately suspects Lupe's condition stems from drug abuse, while Chase looks for other possibilities, such as toxins, in Lupe's apartment. Lupe senses Foreman's disdain for the decisions she's made in her life, and Foreman grapples with his own humble past when his parents come to visit him. When Lupe's symptoms worsen and her organs begin to shut down, Foreman and the team suspect cancer to be the culprit. Meanwhile, Cuddy and Wilson go out on a date to see an art exhibit together, and House probes Wilson's ex-wife about Wilson and his dating habits. When the team learns some devastating news about Lupe's condition, they realize that their own decisions, rather that Lupe's, may cost Lupe her life.

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