When an office building collapses, House has to work fast to diagnose a young woman, Megan, who survived the disaster. Due to her injuries, Megan's only form of communication is blinking. House, without a team since Foreman and Cameron quit and he fired Chase, talks through his ideas with a janitor at the hospital. As Megan's condition worsens, Cuddy puts pressure on House to hire a new team, but House defiantly ignores her, and Wilson resorts to desperate measures and hits House where he knows it will hurt. As House persists in diagnosing Megan by himself, he realizes that the case is not what it appears, and that solitude may not be the answer.