House is recruited by the CIA to help diagnose a deathly ill agent with an unknown illness. The agent's medical case is being spearheaded by Dr. Samira Terzi (guest star Michael Michele), who offers up very little information about the agent's history or previous assignments. With limited information to go on, House uses some unorthodox methods to try to crack the code and determine a diagnosis in time to save his mystery patient's life. Meanwhile, Foreman faces resistance from the remaining six fellowship candidates when they question his judgment and argue over the diagnosis of a female drag car racer who passed out after a race.