House and the team encounter a woman admitted to Princeton-Plainsboro after she collapsed at her wedding. Her test results come up negative for a variety of common diseases, which leads the team to suspect foul play. When they discover the woman had been a music producer living in the fast lane until she converted to Hasidic Judaism, House insists that people do not change so easily, and that her seemingly rash decision may have something to do with an underlying condition. The woman's husband insists that House treat his wife for her illness, rather than for her past, but she continues to fall dangerously ill. The team must run through all possible diagnoses without disturbing her newly found religious beliefs before it is too late. Meanwhile, House is preoccupied by Wilson's newly-outed relationship with a woman whose personality is remarkably similar to House's.