Dr. Pratt (Mekhi Phifer) and Dr. Brenner (guest star David Lyons) get off to a rocky start when Brenner refuses to teach the interns. Gates (John Stamos) treats a young transplant patient with major heart trouble. Abby (Maura Tierney) contemplates telling Kovac (Goran Visnjic) the truth about her affair as she heads for Croatia. Meanwhile, Sam (Linda Cardellini) finds out that Gates and Julia (guest star Reiko Aylesworth) have broken up.