House is convinced one of the actors on his favorite soap opera (guest star Jason Lewis) "Prescription Passion" has a serious medical condition after observing his symptoms on television. House decides to intervene and take matters into his own hands, but both the actor and House's own team dismiss House's assessment and do not believe there is anything wrong with him. Meanwhile, much to House's delight, Amber and Wilson have their first argument, and Cuddy tries to keep up appearances when an inspector makes an unexpected visit to Princeton-Plainsboro.