When a woman with whom Thirteen had a one-night stand falls ill and has a seizure at Thirteen's apartment after a night of partying, Thirteen accompanies the woman to Princeton-Plainsboro where House and the team take on her case. House jumps on the opportunity to delve into Thirteen's personal life, and he and Foreman search Thirteen's apartment to find any possible causes of the woman's illness. Thirteen suspects the woman's drug use has caused her condition, but she soon finds the patient has a long medical history and has seen several doctors over the past few years. She soon finds out the patient slept with her only to get to Dr. House, and that she had been trying to get House to take her as a patient for over a year. Foreman sees evidence of Thirteen's hard-partying lifestyle and confronts her about her self-destruction, warning her that her attitude is sending her life and her job into a downward spiral. Meanwhile, House keeps his private investigator, Lucas (guest star Michael Weston), hot on Wilson's trail.

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