A frantic Sam and too-calm Luka report diabetic Alex missing after he runs away to find his father. Acting on information from the police they follow a lead to Iowa, then eventually head for Colorado. As they travel, they discuss their relationship, slowly realizing they have very little in common. With Alex safe, Sam tells him the truth and takes him to see his father. In the ER Susan, Pratt and the nurses evaluate Ray, Neela, and Abby’s first days at R2’s as each struggles to manage patients, new interns and their first attempts at teaching - badly.