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House is forced to respond in court to the criminal charges against him regarding illegal possession of narcotics, and the judge sets a date for a preliminary hearing. Enough is enough for Cuddy, who insists that House apologize to Detective Tritter as a final attempt to stay out of jail, since he refused to respond to Tritters previous deal by the deadline. Meanwhile, the case of Derek Hoyt, a firefighter suffering from extreme body temperatures and disorientation, leads the team to believe their patient is suffering from an extreme hormone imbalance, but Derek has a violent reaction to their course of treatment, potentially causing serious bodily harm to Cameron in the process. Clearly distracted from Dereks case, House stuns the team when he makes a shocking revelation in an attempt to save himself from jail time. As Dereks condition worsens, the team must try to solve the mystery of his illness without Houses help, but information from Derek sends them in the wrong direction and leads Derek to choose a risky, radical treatment on his brain which, if he survives it, will kill the person he currently is in order to hide a secret hes not willing to reveal.
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