Bernie Mac is a world famous stand-up comedian living the good life in his Los Angeles homestead complete with beautiful wife Wanda and hi-tech SUV. Life was sweet for the Mac-Man. Then one day Bernie's sister in Chicago is sent to rehab for drug use and so her three children: teenage adolescent Vanessa, asthmatic weaseling Jordan, and sweet, innocent Bryana, are taken into Bernie's custody. Raising kids is hard! Especially these kids. Always giving poor Uncle Bernie trouble, making Bernie wanting to "bust their heads 'til the white meat shows".