Kobayakawa Sena is a freshman in high school; taking an opportunity he joined an American Football Club as a manager. Hiruma was a dirty person and also the club owner, he made Sena pretend to be Eye Shield 21, a mysterious running back with lightning speed legs.
Opening Theme:
"Break Through" by Coming Century
#1: "Break Through" by Coming Century [eps 01-35]
#2: "Innocence" by 20th Century [ep 36- 64]
#3: "Dang Dang" by ZZ
Ending Theme:
"Be Free" by Rikkenzu
#1: "Be Free" by Rikkenzu [eps 01-13]
#2: "Blaze Away" by The Trax [eps 14-35]
#3: "Goal" by Beni Arashiro [ep 36- 64]
#4: "Run to Win!" by Aya Hirano, Miyu Irino, Koichi Nagano, Kappei Yamaguchi
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