| Artist | Album | Song Title | Start/Stop | Scene |
| 1x01 - Pilot: |
| Peter Bjorn And John | Writer's Block | | 00:00:00 - 00:01:26 (TV) | At the beginning of the episode. |
| Rihanna | A Girl Like Me | If It's Lovin' That You Want | 00:01:41 - 00:03:13 (TV) | At the party. |
| Justin Timberlake | FutureSex / LoveSounds | What Goes Around...Comes Around | 00:03:13 - 00:05:31 (TV) | Serena arrives at the party. |
| Washington Social Club | Bigger Than Your Boyfriend | Diamond Hipster Boyfriend | 00:07:34 - 00:08:55 (TV) | Jenny putting invitations in envelopes. |
| Antonio Vivaldi | Marie Antoinette OST | Concerto in G (Brian Reitzell) | 00:09:43 - 00:10:39 (TV) | Riding the bus. |
| The Mooney Suzuki | Have Mercy | | 00:12:32 - 00:13:21 (TV) | Hanging up flyers and talking about myspace. |
| Amy Winehouse | Back to Black | | 00:16:05 - 00:17:27 (TV) | Serena talks to Blair about boarding school. |
| Who Made Who | Who Made Who | | 00:18:36 - 00:19:46 (TV) | Jenny talking to Dan about Serena. |
| Air | Pocket Symphony | | 00:21:08 - 00:25:10 (TV) | Serena remembering the Shepard wedding. |
| Cold War Kids | Robbers & Cowards | | 00:28:34 - 00:29:40 (TV) | Blair and her boyfriend make up at the restaurant. |
| Albert Hammond Jr. | Yours to Keep | | 00:32:22 - 00:33:25 (TV) | Blair & friends in the limousine on the way to the party; Dan picking up Serena. |
| Tim 'Timbaland' Mosley | Timbaland Presents Shock Value | The Way I Are (Feat. Keri Hilson and D.O.E.) | 00:33:25 - 00:34:38 (TV) | Blair arriving at the party, Chuck introducing himself to Jenny. |
| Hanson | The Walk | | 00:34:38 - 00:35:44 (TV) | Dan introducing Serena to his dad Rufus. |
| Akon | Konvicted | | 00:35:44 - 00:36:51 (TV) | Chuck kissing Jenny in the stairway. |
| Angels and Airwaves | We Don't Need to Whisper | | 00:40:12 - 00:41:55 (TV) | Dan, Jenny and Serena going home. |
| 1x02 - The Wild Brunch: |
| Gia Farrell | Happy Feet OST | | 00:02:54 - 00:03:32 (TV) | At the beginning of the episode during brunch preparation. |
| Rihanna | Good Girl Gone Bad | | 00:09:18 - 00:10:20 (TV) | Serena calling Blair; The Brunch menu. |
| Rooney | Calling the World | When Did Your Heart Go Missing | 00:10:20 - 00:11:39 (TV) | Serena and Lillian talk while Serena gets ready to see Blair. |
| Ferraby Lionheart | Ferraby Lionheart EP | The Ballad Of Gus And Sam | 00:21:45 - 00:22:48 (TV) | Dan and Serena talking in front of the hotel. |
| Gym Class Heroes | As Cruel as School Children | | 00:25:00 - 00:29:00 (TV) | The beginning of the brunch. |
| Rihanna | Good Girl Gone Bad | | 00:30:12 - 00:32:39 (TV) | Nate and Serena running after Blair. |
| The Bravery | The Sun And The Moon | | 00:36:41 - 00:38:50 (TV) | At the end of the episode. |
| 1x03 - Poison Ivy: |
| Constance Billard Choir | | | 00:02:01 - 00:03:11 (TV) | At the assembly. |
| will.i.am | Songs About Girls | | 00:08:41 - 00:10:22 (TV) | The girls play hockey. |
| The Marlows | | | 00:15:00 - 00:16:34 (TV) | Dan comes home and Rufus talks to him. |
| The Lights | Grand Union | Raise Your Hand (LifebloodRemix) | 00:16:57 - 00:17:46 (TV) | Chuck following Serena walking to the treatment center. |
| Leslie Feist | The Reminder | | 00:21:12 - 00:22:33 (TV) | Rufus tells Dan he's got a position at the Ivy League party. |
| Ladyhawke | | | 00:24:24 - 00:26:24 (TV) | At the Ivy League party. |
| 1x04 - Bad News Blair: |
| Early Earl | | Bounce Back (Ft. Miss Eighty 6) | (TV) | |
| Miss Eighty6 | | | (TV) | |
| Invisible Men | | | (TV) | |
| Henry Mancini | Breakfast At Tiffany's OST | | (TV) | |
| X5 | Epic Movie | | (TV) | |
| Miss Eighty6 | | | (TV) | |
| Alana D | | | (TV) | |
| Eve | Here I Am | | 00:07:32 - 00:09:16 (TV) | Chuck and Nate catching up with Carter. |
| Sean Kingston | Sean Kingston | | 00:40:00 - 00:41:29 (TV) | At the end of the episode. |
| 1x05 - Dare Devil: *(Additional music info in episode details) |
| (None known) | | | | |
| 1x06 - The Handmaiden's Tale: *(Additional music info in episode details) |
| (None known) | | | | |
| 1x07 - Victor, Victrola: *(Additional music info in episode details) |
| (None known) | | | | |
| 1x08 - Seventeen Candles: |
| Two Hours Traffic | | | (TV) | |
| The Virgins | The Virgins '07 EP | | (TV) | |
| Cast | | | (TV) | |
| Eskimo Joe | | | (TV) | |
| Miss Eighty6 | | | (TV) | |
| Dawn Landes | Dawn's Music | | (TV) | |
| The Virgins | The Virgins '07 EP | Love Is Colder Than Death | (TV) | |
| The Virgins | The Virgins '07 EP | | (TV) | |
| The Virgins | The Virgins '07 EP | | 00:04:42 - 00:06:09 (TV) | Blair and Chuck talk on her way to the jeweller. |
| The Shapes | | | 00:10:18 - 00:11:07 (TV) | Blair and Serena talking about Nate. |
| The Virgins | The Virgins '07 EP | | 00:11:07 - 00:11:38 (TV) | Nate is listening to this song as his mother is talking to him. |
| Puffy Ami Yumi | Splurge | | 00:17:41 - 00:18:58 (TV) | At Blairs birthday party when Serena and Blair arrive. |
| Pinback | Autumn of the Seraphs | | 00:21:46 - 00:23:34 (TV) | Jenny & Nate go for a walk; Vanessa and Dan arrive at Blairs party. |
| 1x09 - Blair Waldorf Must Pie!: |
| Nelly Furtado | Loose | | 00:01:16 - 00:01:57 (TV) | Blair and Serena on thanksgiving the year before. |
| Bonobo | Days to Come | | 00:07:49 - 00:09:30 (TV) | Last thanksgiving at the Waldorfs when Nate arrives. |
| OK Go | Oh No | | 00:13:46 - 00:14:23 (TV) | Last thanksgiving at the Humphreys. |
| Will Dailey | Back Flipping Forward | | 00:18:18 - 00:19:40 (TV) | Serena getting a phone call at the current thanksgiving at the Humphrey's. |
| Sebastien Tellier | | | 00:20:58 - 00:22:22 (TV) | Nate and Serena in the bathroom at last years thanksgiving. |
| Stickboy | | | 00:31:23 - 00:32:08 (TV) | When Blair, Serena, Dan, Erik and Jenny eat. |
| Vanessa Carlton | Heroes & Thieves | | 00:38:09 - 00:40:06 (TV) | End of last years and current thanksgiving. |
| 1x10 - Hi, Society: |
| Mel Tormé | | | 00:01:01 - 00:03:09 (TV) | At the beginning of the episode. |
| The Pierces | | | 00:03:09 - 00:05:04 (TV) | At Prescott Dance Studio |
| High Society | | | 00:06:20 - 00:07:04 (TV) | Chuck and Blair making out. |
| Lissa | | | 00:12:17 - 00:13:21 (TV) | Lily & Jenny are shopping and meet Alison. |
| Rooney | Calling the World | | 00:28:56 - 00:29:34 (TV) | At Alison's art show. |
| The Pierces | Thirteen Tales of Love and Revenge | | 00:29:34 - 00:30:40 (TV) | At the Waltz at the debutante ball. |
| Rooney | Calling the World | | 00:32:03 - 00:32:23 (TV) | Dan gets a call at the art show. |
| The Pierces | Thirteen Tales of Love and Revenge | | 00:34:17 - 00:36:50 (TV) | Chuck and Blair argue; Serena and her grandmother talk; Dan & Serena dance |
| OneRepublic | Dreaming Out Loud | Apologize (Feat. Timbaland) | 00:39:14 - 00:41:31 (TV) | At the end of the episode. |
| 1x11 - Roman Holiday: *(Additional music info in episode details) |
| The Plush Interiors | | | 00:10:17 - 00:11:10 (TV) | Dan and Vanessa talk in the cafe. |
| Two Hours Traffic | | | 00:12:30 - 00:13:09 (TV) | Rufus meeting Alex in the bar. |
| The McGuire Sisters | | | 00:13:18 - 00:14:06 (TV) | Blair, Roman and Harold ice skating. |
| The Dan Band | | | 00:16:51 - 00:17:28 (TV) | Dan and Jenny at the cafe trying to find a christmas gift for Serena. |
| The Republic Tigers | | | 00:19:04 - 00:20:04 (TV) | Serena asking Vanessa for advice for a gift for dan. |
| Band of Horses | Cease to Begin | | 00:32:49 - 00:35:55 (TV) | Blairs christmas gift from her dad, Serena gives Dan her gift. |
| The Weepies | Happiness | | 00:38:51 - 00:42:08 (TV) | At the end of the episode. |
| 1x12 - School Lies: |
| Moby | | | 00:00:57 - 00:03:44 (TV) | At the beginning of the episode. |
| LCD Soundsystem | Sound of Silver | | 00:05:21 - 00:06:12 (TV) | Dan and Vanessa arriving at the pool party. |
| The Filthy Youth | | Come Flash All Your Ladies | 00:13:57 - 00:15:38 (TV) | Dan and Vanessa arrive at Blair's. |
| The Filthy Youth | | | 00:16:39 - 00:18:18 (TV) | Dan explains his point of view to Serena, Chuck confronts Blair. |
| Harry Warren | | | 00:23:39 - 00:24:40 (TV) | Bart and Lily are having lunch. |
| Oppenheimer | | | 00:33:44 - 00:34:53 (TV) | Blair visits Vanessa at her workplace. |
| OneRepublic | Dreaming Out Loud | | 00:36:06 - 00:37:42 (TV) | Bart is toasting his & Lily's engagement and Lily meets with Rufus |
| Antonín Dvorák | | Four Romantic Pieces, Opus 75 | 00:37:45 - 00:38:22 (TV) | Chuck and Serena's first brother/sister squabble. |
| Wolfgang Amadeus Mozart | | | 00:39:09 - 00:40:01 (TV) | Bart tells Serena how he helped her out. |
| La Rocca | | | 00:40:01 - 00:41:51 (TV) | At the end of the episode. |
| 1x13 - A Thin Line Between Chuck and Nate: *(Additional music info in episode details) |
| Nadia Oh | Hot Like Wow | | 00:00:58 - 00:01:47 (TV) | At the beginning of the episode. |
| Falling Up | | The Dark Side Of Indoor Track Meets | 00:03:35 - 00:04:37 (TV) | Dan tells Serena he will support her. |
| Machine Translations | | | 00:06:35 - 00:07:32 (TV) | Nate asks Blair for a favor. |
| Dashboard Confessional | The Shade of Poison Trees | | 00:11:54 - 00:13:05 (TV) | Bex visits Rufus' gallery. |
| Falling Up | | The Dark Side Of Indoor Track Meets | 00:19:10 - 00:21:32 (TV) | Dan and Serena are having a picnic and the rumor spreads. |
| Figurines | | | 00:28:35 - 00:29:53 (TV) | Dan dislikes Serena's response to his declaration; Blair remembers her interludes with Nate & Chuck. |
| Dan Cray Trio | | | 00:30:53 - 00:33:09 (TV) | Blair congratulates Chuck on his revenge. |
| Nicole Scherzinger | | | 00:39:01 - 00:41:39 (TV) | Serena asks Blair to stay. |
| 1x14 - The Blair Bitch Project: |
| Henry Mancini | Breakfast At Tiffany's OST | | 00:01:57 - 00:02:47 (TV) | At the beginning of the episode. |
| Deadly Syndrome | The Ortolan | | 00:06:38 - 00:07:49 (TV) | Dan and Rufus eat breakfast. |
| The Teenagers | Reality Check | | 00:13:14 - 00:14:14 (TV) | Serena and Dan make out, Chuck calls them to dinner. |
| Silver Moneyl | | | 00:15:49 - 00:16:24 (TV) | The girls celebraring Blairs humiliation. |
| Miss Eighty6 | | | 00:17:17 - 00:17:26 (TV) | Blair at Butter. |
| Classic | | | 00:34:55 - 00:35:33 (TV) | Blair holding a table at Butter. |
| Kylie Minogue | | | 00:38:05 - 00:38:42 (TV) | Blair goes to the bar. |
| The Kills | Midnight Boom | | 00:38:42 - 00:39:56 (TV) | At the end of the episode. |
| 1x15 - Desperately Seeking Serena: |
| Phantom Planet | Raise The Dead | | 00:01:07 - 00:02:24 (TV) | At the beginning of the episode. |
| Vampire Weekend | Vampire Weekend | | 00:09:47 - 00:11:10 (TV) | Nate bringing Dan books. |
| Crystal Castles | | | 00:11:10 - 00:12:08 (TV) | Serena and Georgina at the club. |
| Difx | | Nice Sweet Sexy (Ft. Imperio & Cru) | 00:13:14 - 00:15:28 (TV) | Serena and Georgina getting drunk. |
| Flo Rida | Mail on Sunday | | 00:19:05 - 00:19:25 (TV) | Song Blair is playing on her phone. |
| The Ting Tings | We Started Nothing | | 00:27:47 - 00:29:56 (TV) | Serena and Georgina at the restaurant. |
| 1x16 - All About My Brother: |
| (None known) | | | | |
| 1x17 - Woman on the Verge: |
| Lisa Loeb | Tails | | | |
| 1x18 - Much 'I Do' About Nothing: |
| (None known) | | | | |