| Artist | Album | Song Title | Start/Stop | Scene |
| Special - Complications of the Heart: |
| (None known) | | | | |
| 3x01 - Time Has Come Today: |
| The Dixie Chicks | Taking The Long Way | | 00:00:00 - 00:44:00 (TV) | At the beginning of the episode. |
| Tegan and Sara | So Jealous | | 00:01:40 - 00:02:14 (TV) | During Izzys flashback when she meets Alex for the first time. |
| Sleeping At Last | Keep No Score | | 00:09:20 - 00:09:47 (TV) | When Richard leaves Ellis. |
| Emilíana Torrini | Fisherman's Woman | | 00:17:35 - 00:19:00 (TV) | During the flashback where Derek and Addison break up. |
| Gnarls Barkley | St. Elsewhere | | 00:19:04 - 00:20:04 (TV) | During the flashback where Cristina introduces herself to Burke. |
| Grant Lee Phillips | Nineteeneighties | | 00:25:16 - 00:26:47 (TV) | During the flashback when Derek and Meredith meet at Joe's. |
| Mat Kearney | Nothing Left to Lose | | 00:38:48 - 00:41:44 (TV) | At the end of the episode. |
| 3x02 - I Am a Tree: |
| Moloko | Things to Make and Do | | 00:00:32 - 00:01:43 (TV) | At the beginning of the episode. |
| Mat Kearney | Nothing Left to Lose | | 00:26:16 - 00:28:02 (TV) | When Benjamin and Jeffrey are being operated on. |
| The Chalets | Check In | | 00:28:03 - 00:30:24 (TV) | When Addison and Bailey talk at Joe's. |
| Bitter:Sweet | The Mating Game | | 00:33:58 - 00:34:20 (TV) | When Dr. Torres dances and Dr. Webber finds her. |
| Jesus Jackson | | | 00:34:30 - 00:36:00 (TV) | When Finn and Derek appear at Joe's. |
| Snow Patrol | Eyes Open | | 00:37:14 - 00:41:58 (TV) | At the end of the episode. |
| 3x03 - Sometimes A Fantasy: |
| Outkast | Idlewild | Idlewild Blue (Don'tchu Worry 'Bout Me) | 00:00:29 - 00:01:30 (TV) | At the beginning of the episode. |
| Lily Allen | Alright, Still | | 00:15:15 - 00:16:18 (TV) | When Derek and Megan do the ice-test. |
| The Pipettes | We Are The Pipettes | | 00:18:27 - 00:19:57 (TV) | When Addison and Mark talk at Joe's. |
| The Bamboos | Step It Up | | 00:21:06 - 00:23:33 (TV) | When the interns are eating lunch. |
| The Poems | Young America | | 00:26:04 - 00:27:50 (TV) | When Derek is operating on Taylor and George talks to Izzy. |
| Joe Purdy | You Can Tell Georgia | | 00:38:45 - 00:42:07 (TV) | At the end of the episode. |
| 3x04 - What I Am: |
| Camera Obscura | Let's Get Out of This Country | | 00:00:32 - 00:02:13 (TV) | At the beginning of the episode. |
| The Gossip | Standing in the Way of Control | Standing In The Way Of Control | 00:05:33 - 00:06:17 (TV) | When all see Marc in the hospital. |
| Au Revoir Simone | Verses of Comfort, Assurance & Salvation | | 00:20:15 - 00:21:53 (TV) | When Denny's Father asks Izzy to make him understand how Denny proposed. |
| Kate Havnevik | Melankton | | 00:22:59 - 00:25:07 (TV) | When Addison tells Meredith how she knew. |
| TV On The Radio | Return to Cookie Mountain | | 00:29:23 - 00:31:50 (TV) | When Meredith is being operated on. |
| Mindy Smith | | | 00:37:42 - 00:42:12 (TV) | At the end of the episode. |
| 3x05 - Oh, The Guilt: |
| Nellie McKay | Get Away from Me | | 00:00:33 - 00:01:54 (TV) | At the beginning of the episode. |
| Kate Havnevik | Melankton | | 00:17:29 - 00:18:40 (TV) | When Meredith bumps into Derek and shows him the X-ray of the stuck couple. |
| The Second Band | | | 00:22:44 - 00:24:26 (TV) | When the interns have lunch and discuss what they'd do with Izzie's money. |
| Fionn Regan | End of History | | 00:33:35 - 00:36:16 (TV) | When Addison confesses she lived with Mark after Derek left her. |
| Keisha White | Out of My Hands | | 00:40:08 - 00:41:48 (TV) | At the end of the episode. |
| 3x06 - Let The Angels Commit: |
| Teddybears | Soft Machine | | 00:00:24 - 00:02:01 (TV) | At the beginning of the episode. |
| Jim Noir | Tower of Love | | 00:03:18 - 00:05:22 (TV) | When Meredith and George are in the elevator. |
| Peter Bjorn And John | Writer's Block | | 00:19:22 - 00:21:15 (TV) | When the interns are having lunch with "really old guy" |
| Gomez | How We Operate | | 00:23:46 - 00:25:56 (TV) | When Cristina and Meredith talk on the stairs. |
| Vega4 | You and Others | | 00:34:22 - 00:37:54 (TV) | When Derek thanks his sister for visiting. |
| The Album Leaf | Into the Blue Again | | 00:39:31 - 00:42:11 (TV) | At the end of the episode. |
| 3x07 - Where The Boys Are: |
| Beck | The Information | | 00:00:29 - 00:01:41 (TV) | At the beginning of the episode. |
| Jim Noir | Tower of Love | | 00:02:20 - 00:03:08 (TV) | When the guys walk to the fishing site. |
| Luke Temple | Hold a Match for a Gasoline World | | 00:13:50 - 00:15:35 (TV) | When Dr. Webber asks Joe about his relationship while fishing. |
| Inara George | | | 00:16:35 - 00:17:44 (TV) | When Donna is being told she has breast-cancer. |
| The Jealous Girlfriends | The Jealous Girlfriends | | 00:21:25 - 00:22:32 (TV) | When Alex and George hear the fighting rules from Dr. Webber. |
| Big Sandy and His Fly-Rite Boys | Its Time! | | 00:25:28 - 00:26:16 (TV) | When Alex and George fight. |
| Brett Dennen | So Much More | | 00:30:58 - 00:33:58 (TV) | When Dr. Webber talks to Alex at the campfire. |
| Bedouin Soundclash | | | 00:33:59 - 00:35:30 (TV) | When Burke asks Derek about Sloan. |
| Bill Ricchini | Tonight I Burn Brightly | A Cold Wind Will Blow Through Your Door | 00:37:57 - 00:42:09 (TV) | At the end of the episode. |
| 3x08 - Staring At The Sun: |
| Lily Allen | Alright, Still | | 00:00:35 - 00:01:52 (TV) | At the beginning of the episode. |
| Get Set Go | Selling Out and Going Home | | 00:19:51 - 00:20:54 (TV) | When the interns are having lunchbreak. |
| The Watson Twins | Southern Manners | | 00:22:18 - 00:24:15 (TV) | When O'Malley tries to tell his dad that he got cancer. |
| Mat Kearney | Nothing Left to Lose | Where We Gonna Go From Here | 00:30:52 - 00:33:55 (TV) | When Mia is having brain surgery. |
| Ingrid Michaelson | Girls & Boys | | 00:37:51 - 00:39:56 (TV) | When Georges' father talks to Cristina about his wife. |
| Chandra Wilson | | | 00:40:20 - 00:42:11 (TV) | At the end of the episode. Bailey sings this song to her son via telephone. |
| 3x09 - From A Whisper To A Scream: |
| The Dears | Gang of Losers | You And I Are A Gang of Losers | 00:30:38 - 00:33:20 (TV) | When Callie tells George on the stairs that she didn't betray him. |
| Damien Rice | 9 | | 00:39:19 - 00:41:51 (TV) | When Burke refuses to accept help from Cristina in the OR. |
| Kate Havnevik | Melankton | | 00:44:20 - 00:48:53 (TV) | After Derek's unpleasant conversation with Burke in the elevator. |
| 3x10 - Don't Stand So Close to Me: |
| Anya Marina | Miss Halfway | | 00:20:47 - 00:21:46 (TV) | When the interns are eating in old guy's room. |
| John Legend | Once Again | | 00:31:14 - 00:33:28 (TV) | When the twins are being separated and Meredith gives news on the baby. |
| Son Volt | Okemah And The Melody Of Riot | | 00:36:54 - 00:41:02 (TV) | At the end of the episode. |
| 3x11 - Six Days (1): |
| The Research | Breaking Up | Lonely Hearts Still Beat The Same | 00:00:41 - 00:02:55 (TV) | At the beginning of the episode. |
| William Fitzsimmons | Until When We Are Ghosts | | 00:21:02 - 00:23:07 (TV) | The song plays as George and his Dad talk before the surgery. |
| Emilíana Torrini | | | 00:27:36 - 00:28:59 (TV) | As George prepares his family to see his father post-operation. |
| Michelle Featherstone | Rest Of My Life [CD Single] | | 00:30:01 - 00:31:26 (TV) | The song plays as Meredith finds Derek in the morning, and Izzie stares down her check on the fridge. |
| Travis | 12 Memories | | 00:39:33 - 00:42:08 (TV) | At the end of the episode. |
| 3x12 - Six Days (2): |
| OK Go | Oh No | | 00:01:07 - 00:01:58 (TV) | At the beginning of the episode (UK Surf Version) |
| Regina Spektor | Begin to Hope | | 00:07:32 - 00:09:31 (TV) | When Addison and Callie talk about Addison's choice to not have Mark's baby. |
| Ingrid Michaelson | Girls & Boys | | 00:22:52 - 00:24:58 (TV) | When Cristina brings Burke his dinner. |
| Susanna & The Magical Orchestra | Melody Mountain | | 00:29:39 - 00:32:07 (TV) | The song plays as the O'Malley family makes a decision about George's dad. |
| Gary Jules | Gary Jules | | 00:34:44 - 00:38:44 (TV) | As Burke, Cristina and Derek talk about Mr. O'Malley. |
| The Slip | Eisenhower | | 00:39:51 - 00:42:03 (TV) | At the end of the episode. |
| 3x13 - Great Expectations: |
| Lily Frost | Cine-Magique | | 00:00:33 - 00:01:50 (TV) | At the beginning of the episode. |
| The Umbrellas | Illuminare | | 00:24:01 - 00:25:46 (TV) | When Callie, Cristina and Richard operate on a patient. |
| Skye | Mind How You Go | | 00:38:08 - 00:42:11 (TV) | At the end of the episode. |
| 3x14 - Wishin' and Hopin': |
| Psapp | The Only Thing I Ever Wanted | | 00:00:22 - 00:01:46 (TV) | At the beginning of the episode. |
| Beck | The Information | | 00:10:03 - 00:11:04 (TV) | When Izzie and Alex offer a patient a free consultation. |
| Miho Hatori | Ecdysis | | 00:16:52 - 00:17:56 (TV) | When Meredith warns Derek about her mother but Derek talks to Ellis anyway. |
| Iain Archer | Magnetic North | | 00:28:08 - 00:29:48 (TV) | As Meredith talks with Richard about life and change. |
| Susanna & The Magical Orchestra | List of Lights and Buoys | | 00:37:41 - 00:40:24 (TV) | As Richard and Ellis talk about Meredith and their past relationship. |
| The Whitest Boy Alive | Dreams | | 00:41:05 - 00:42:35 (TV) | As Cristina and Burke share a moment. |
| 3x15 - Walk on Water: |
| Radio Citizen | Berlin Serengeti | | 00:00:28 - 00:03:02 (TV) | At the beginning of the episode. |
| Union of Knives | Violence & Birdsong | | 00:12:33 - 00:13:30 (TV) | Bailey tells interns to get out there and help people, Meredith tends to the wounded. |
| 8mm | Songs to Love and Die by... | | 00:22:18 - 00:24:18 (TV) | When Izzie tells Vince to find search and rescue and Derek asks Meredith if she is upset. |
| Snow Patrol | Eyes Open | | 00:37:36 - 00:42:07 (TV) | At the end of the episode. |
| 3x16 - Drowning on Dry Land: |
| Butterfly Boucher | | | 00:00:27 - 00:02:00 (TV) | At the beginning of the episode. |
| Kate Havnevik | Melankton | | 00:22:21 - 00:23:28 (TV) | After Izzie drilled into the patients head and the girl stares at the water. |
| Patrick Watson | Close to Paradise | | 00:26:09 - 00:29:19 (TV) | When Alex posts pictures from the morgue. |
| Butterfly Boucher | | | 00:36:45 - 00:38:53 (TV) | At the end of the episode as the doctors work on Meredith. |
| 3x17 - Some Kind of Miracle: |
| Aqualung | Memory Man | | 00:00:21 - 00:02:15 (TV) | At the beginning of the episode. |
| Damien Rice | 9 | | 00:26:21 - 00:28:00 (TV) | As Meredith's heart flatlines. |
| Unkle Bob | Sugar & Spite | | 00:39:26 - 00:42:10 (TV) | At the end of the episode. |
| 3x18 - Scars and Souvenirs: |
| Koop | Come to Me | | 00:00:34 - 00:02:39 (TV) | At the beginning of the episode. |
| Gomez | How We Operate | | 00:10:46 - 00:13:10 (TV) | When Cristina tells Colin she's marrying Burke. |
| Psapp | The Only Thing I Ever Wanted | | 00:15:11 - 00:17:25 (TV) | The song plays as Meredith tells Derek she is having dinner with her dad. |
| Wild Sweet Orange | | | 00:28:03 - 00:30:21 (TV) | When the fuse blows during the dinner. |
| Anya Marina | Move You / Not A Through Street [CD Single] | Move You (Slow & Steady Seduction Phase II) | 00:39:26 - 00:42:10 (TV) | At the end of the episode. |
| 3x19 - My Favorite Mistake: |
| Mirah | Joyride: Remixes | La Familia (Remix by Guy Sigsworth) | 00:00:24 - 00:01:00 (TV) | At the beginning of the episode. |
| Alamo Race Track | | | 00:21:36 - 00:23:21 (TV) | When the interns are having lunch. |
| Adam Merrin | Have One | | 00:25:56 - 00:27:30 (TV) | As George has a flashback to the night before. He confronts Izzie. |
| Let's Go Sailing | The Chaos in Order | All I Want From You Is Love | 00:34:12 - 00:35:29 (TV) | As Meredith harvests bone, and Cristina amputates a foot. |
| Let's Go Sailing | The Chaos in Order | | 00:39:46 - 00:43:35 (TV) | At the end of the episode. |
| Special - Every Moment Counts: |
| (None known) | | | | |
| 3x20 - Time After Time: |
| Amy Winehouse | Back to Black | | 00:00:23 - 00:01:09 (TV) | Song plays as Burke and Cristina operate on a a patient. |
| The Whitest Boy Alive | Dreams | | 00:03:35 - 00:04:52 (TV) | Song plays as Cristina and Meredith discuss Colin and Susan. Alex asks for Cristina's help. |
| Nouvelle Vague | Bande a Part | | 00:20:47 - 00:22:15 (TV) | Song plays as the interns hang out in the clinic and talk about their patients. |
| Maria Taylor | Lynn Teeter Flower | | 00:28:45 - 00:31:43 (TV) | Song plays as George helps Izzie while she tells him about her family. |
| Lullaby Baxter | Garden Cities of To-morrow | | 00:33:44 - 00:35:26 (TV) | Song plays as George takes Izzie to pediatrics before Derek asks Bailey for advice about Meredith. |
| Maria Taylor | Lynn Teeter Flower | | 00:37:35 - 00:39:14 (TV) | Song plays as Ava argues with Alex. Burke and Cristina talk at home. Susan confronts Meredith and they have a heart to heart. Addison finds Richard hitting on a woman. |
| Maria Taylor | Lynn Teeter Flower | | 00:40:30 - 00:42:13 (TV) | Addison finds Richard hitting on a woman. |
| 3x21 - Desire: |
| The Reddmen | | The Secrets of Amanda Prine | 00:00:30 - 00:02:18 (TV) | At the beginning of the episode. |
| Let's Go Sailing | The Chaos in Order | | 00:14:55 - 00:16:35 (TV) | While Callie and Addison talk about relationships and Jane Doe overhears the conversation. |
| The Bird & The Bee | The Bird & The Bee | | 00:22:50 - 00:24:05 (TV) | As the interns continue studying, while testing out wedding cakes. |
| Beck | The Information | | 00:26:41 - 00:29:03 (TV) | During various operations after Callie talked to Izzie in the elevator. |
| Anna Waronker | Anna By Anna Waronker | | 00:38:46 - 00:42:15 (TV) | At the end of the episode. |
| 3x22 - The Other Side of This Life (1): |
| Leslie Feist | The Reminder | | 00:00:35 - 00:01:48 (TV) | At the beginning of the episode. |
| The Mary Onettes | Mary Onettes | | 00:02:22 - 03:15:00 (TV) | As Addison drives along the coast and enters the Wellness Clinic. |
| The Broken West | I Can't Go On, I'll Go On | | 00:06:35 - 00:07:38 (TV) | As Addison enters the Wellness Clinic and finds Naomi. |
| Switches | Heart Turned to D.E.A.D. | | 00:17:53 - 00:18:22 (TV) | During the fight. |
| The Rosewood Thieves | From the Decker House | | 00:23:01 - 00:24:42 (TV) | During couples therapy at the Wellness Center. |
| Jem | Just a Ride Pt.1 | | 00:28:49 - 00:32:06 (TV) | As Naomi and Addison talk and Violet runs into her ex. |
| The Adored | A New Language | | 00:33:04 - 00:34:14 (TV) | As Cooper cries over his stripped vehicle. |
| Brandi Carlile | The Story | | 00:41:55 - 00:42:57 (TV) | After Addison got the bad news and yells at the elevator to stop talking. |
| 3x23 - The Other Side of This Life (2): |
| A.B. O'Neill | | | 00:00:49 - 00:02:10 (TV) | As Naomi, Addison and Violet wait for Dell to walk by to go surfing during his lunch break. |
| Psapp | Tiger My Friend | | 00:05:04 - 00:07:15 (TV) | As Addison goes into Pete's office and gets acupuncture. |
| Tim Myers | | | 00:10:17 - 00:11:59 (TV) | While Ava/Jane Doe is in brain surgery, and as Addison delivers Lisa's baby. |
| Candi Staton | His Hands | | 00:18:46 - 00:19:48 (TV) | As Pete kisses Addison in the hallway to remind her that she is not "dried up." |
| Kate Walsh | Tim's House | | 00:22:01 - 00:24:20 (TV) | As a couple learns one of them is sick, and Addison apologizes to the elevator voice. |
| Robert Randolph & The Family Band | Colorblind | Ain't Nothing Wrong With That | 00:26:22 - 00:28:52 (TV) | As Dell tries to get Naomi to go out with him. Addison goes out on the town with the folks from the Wellness Center, and Cooper tries to kiss Violet. |
| Lay Low | | | 00:33:15 - 00:35:36 (TV) | As Addison, Naomi and Sam look on Carol with the new baby. Izzie and George talk in the elevator about George leaving for Mercy West. |
| Bloc Party | A Weekend in the City | | 00:36:07 - 00:41:59 (TV) | As Meredith tells her father Susan died. Burke and Cristina talk at the end of the day. The interns drink Tequila at the end of the night. Addison leaves the Wellness Center and California. |
| 3x24 - Testing 1-2-3: |
| Let's Go Sailing | The Chaos in Order | | 00:00:33 - 00:03:51 (TV) | At the beginning of the episode. |
| Amy Winehouse | Back to Black | | 00:28:37 - 00:30:13 (TV) | As George tries to talk to the Chief. The doctors operate on the mountain climbers. |
| Ingrid Michaelson | Girls & Boys | | 00:30:54 - 00:32:35 (TV) | As Alex and Ava argue. Izzie tries to talk with George but gets upset. |
| The Weather Machines | The Sound Of Pseudoscience | | 00:35:06 - 00:36:54 (TV) | As Addison joins Burke's bachelor party at the bar. |
| Paolo Nutini | These Streets | | 00:38:48 - 00:42:03 (TV) | At the end of the episode. |
| 3x25 - Didn't We Almost Have It All: |
| The Jealous Girlfriends | The Jealous Girlfriends | | 00:01:37 - 00:02:52 (TV) | At the beginning of the episode. |
| Grace Potter | This Is Somewhere | | 00:09:06 - 00:11:05 (TV) | As Cristina is unable to sleep, Alex watches Ava and her husband talk, Derek talks to Meredith about his night. |
| Ray LaMontagne | Trouble | | 00:20:52 - 00:24:41 (TV) | As Burke practices his wedding vows, Callie and George talk about having a baby, Alex talks with Ava's husband while he holds the baby. |
| Coburn | Coburn | | 00:29:33 - 00:31:53 (TV) | As Cristina operates. Izzie helps George with his tie and declares her feelings. |
| Ray LaMontagne | Till the Sun Turns Black | | 00:33:34 - 00:38:46 (TV) | As the interns get the results of their intern test results. Ava asks Alex to giv eher a reason to stay. Meredith and Derek have a heart to heart. |
| The Hereafter | the hereafter | | 00:39:48 - 00:42:40 (TV) | As Alex talks to Addison about Ava. George and Bailey talk about his results. The girls get ready for the wedding. |
| The Mary Onettes | Mary Onettes | | 00:44:40 - 00:45:19 (TV) | As Cristina readies herself for the aisle & Burke goes to check up on Cristina. |
| Ingrid Michaelson | | | 00:46:34 - 00:52:09 (TV) | At the end of the episode. |