| Artist | Album | Song Title | Start/Stop | Scene |
| 5x01 - Dream A Little Dream Of Me (1): |
| (None known) | | | | |
| 5x02 - Dream A Little Dream Of Me (2): |
| (None known) | | | | |
| 5x03 - Here Comes the Flood: |
| (None known) | | | | |
| 5x04 - Brave New World: |
| (None known) | | | | |
| 5x05 - There's No 'I' in Team: |
| (None known) | | | | |
| 5x06 - Life During Wartime: |
| (None known) | | | | |
| 5x07 - Rise Up: |
| (None known) | | | | |
| 5x08 - These Ties That Bind: |
| The Flying Tourbillon Orchestra | | | 00:00:00 - 00:02:15 (TV) | At the beginning of the episode. |
| Seabird | 'Til We See the Shore | | 00:30:53 - 00:33:40 (TV) | During the operation on Timothy. |
| Lenka | Lenka | | 00:37:03 - 00:40:35 (TV) | At the end of the episode. |
| 5x09 - In The Midnight Hour: |
| (None known) | | | | |
| 5x10 - All By Myself: |
| Sugarush Beat Company | | | 00:00:00 - 00:02:31 (TV) | At the beginning of the episode. |
| Ray LaMontagne | Gossip In The Grain | | 00:23:50 - 00:25:37 (TV) | Dr. Dixon tries to convince Holly's family to donate her organs. |
| Max Morgan | | | 00:28:27 - 00:31:20 (TV) | Cristina has to make her decision. Cristina chooses Alex for the solo surgery. Alex tells Izzie he loves her. |
| Kanye West | 808s | | 00:37:51 - 00:42:12 (TV) | At the end of the episode. |
| 5x11 - Wish You Were Here: |
| Daniel Powter | Under the Radar | | 00:00:00 - 00:01:01 (TV) | Cristina stands on the vent as it blows her hair. Meredith asks Derek for a quickie. They make out. |
| Ben Folds | Way to Normal | | 00:22:05 - 00:24:01 (TV) | Callie and Mark invent a no-sex-with-interns 12-step program. George reminds Alex it's Izzie's birthday. Everyone discusses William Dunn. Owen blows off Cristina. |
| The Coral Sea | Firelight | | 00:31:44 - 00:33:44 (TV) | Arizona snaps at Bailey over Jackson's treatment options. Cristina leaves the room when Mer enters. Owen asks if Cristina wants to get a drink. She tells him to leave her alone. |
| Dido | Safe Trip Home | | 00:34:39 - 00:36:26 (TV) | Sadie tells Mer to make a sincere apology to Cristina. Bailey tells Jackson and Melinda that Jackson needs organ transplants. Alex helps Jackson with his Wish List. |
| Santogold | Santogold | | 00:36:43 - 00:38:01 (TV) | Margaret tells George, Mark and Callie she's going to Denver. Callie and Mark try to avoid looking at the interns. Mark leaves with Lexie. |
| Tandy | To A Friend | | 00:40:17 - 00:41:51 (TV) | Derek dances with Mer to cheer her up. Alex gives Izzie a cake he baked her. She blows the candle out. |
| 5x12 - Sympathy for the Devil: |
| Winterpills | Central Chambers | | 00:00:00 - 00:01:19 (TV) | At the beginning of the episode. |
| Anya Marina | Slow | | 00:15:15 - 00:17:21 (TV) | Arizona asks Alex what his plans are with Izzie. Meredith checks on William. Derek tries to stop Canyon from talking about Meredith. Lexie, Ryan and Megan sit down with Mark. |
| Right Away, Great Captain | The Eventually Home | | 00:28:23 - 00:30:56 (TV) | Cristina tells Meredith her ponytail look ridiculous. Carolyn gives Mark her blessing regarding Lexie. Callie and Mark tell Chuck he's shorter. Gary airs his grievances to Chuck. |
| Glass Pear | | | 00:33:04 - 00:37:07 (TV) | Meredith tells Carolyn what kind of girl she really is. Izzie breaks up with Mason. Before leaving for the night with Lexie, Mark tells Callie to walk tall. Owen arrives at Cristina's apartment drunk. Carolyn gives Derek her engagement ring. |
| Johnathan Rice | Trouble is Real | | 00:37:35 - 00:40:11 (TV) | Owen, clothed in the shower, tells Cristina about his best surgery. She helps him undress. Alex wants to introduce Izzie to his mom. After Izzie leaves, Mason sits down to talk to Alex. |
| 5x13 - Stairway to Heaven: |
| Emilíana Torrini | Me and Armini | | 00:27:15 - 00:29:58 (TV) | Jackson crashes. Melinda panics. William is stabilized. Izzi calms Melinda. |
| Bon Iver | For Emma, Forever Ago | | 00:29:58 - 00:33:19 (TV) | Richard harvests the organs. Kelly signs the organ donation forms. Melinda paces. Jackson crashes again. Mason leaves Izzie. |
| Powderfinger | Dream Days at the Hotel Existence | | 00:37:21 - 00:42:14 (TV) | At the end of the episode. |
| 5x14 - Beat Your Heart Out: |
| Nikka Costa | Pebble to a Pearl | | 00:00:00 - 00:03:25 (TV) | At the beginning of the episode. |
| Panda Transport | | | 00:21:44 - 00:23:31 (TV) | Dixon tells Dan and Lisa that Stacy may be bedridden for years. George warns Izzie. Mer tells Cristina that she's worried Derek will hate her babies. Mer gives Derek the cold shoulder. |
| Trolle Siebenhaar | | | 00:23:44 - 00:24:49 (TV) | Jen warns Derek to propose soon. The gang discusses the virtues of the different sex techniques in the magazine article. |
| Bon Iver | For Emma, Forever Ago | | 00:27:59 - 00:30:12 (TV) | Derek tells Jen she has an aneurysm. Dixon explains to Bailey and Cristina how the hugging technique works. Richard and Alex remove Warren's sex toy. Bailey and Cristina reluctantly stop hugging Dixon. |
| Kate Havnevik | | | 00:36:40 - 00:38:13 (TV) | Arizona tells Bailey she belongs in peds. Lexie sits with Callie at the bar. Callie goes to the ladies' room upset. Cristina reads Ellis' journal while Owen sleeps with his head on her lap. She tells Mer about Chief's failed proposal. |
| Dido | Safe Trip Home | Never Want To Say It's Love | 00:39:28 - 00:42:07 (TV) | At the end of the episode. |
| 5x15 - Before and After: |
| Keri Noble | Keri Noble | | 00:00:00 - 00:01:48 (TV) | Richard probes Derek for good news as they await Addison, Naomi, and Archer in the ambulance. Surrounded in foil, Izzie tells Alex she's making a game for the interns. |
| Liam Finn | I'll Be Lightning | | 00:16:06 - 00:18:20 (TV) | Bailey, Richard, Naomi, Sam and Callie watch Addison sitting in the chapel. Callie shows Addison how to pray. |
| Shontelle | Shontelligence | | 00:28:54 - 00:30:28 (TV) | Izzie is brainstorming for a prize with Alex. Richard leaves surgery and sees the interns cross the finish line. He tells them their prize. Owen tells Beth. |
| Ingrid Michaelson | | | 00:30:49 - 00:34:48 (TV) | Owen tells Beth about her dad. Meredith and Cristina consider how much they don't know Derek and Owen. George offers help to Sadie. Owen pulls Cristina into an on-call room. Owen pleads with Cristina. |
| Slow Runner | No Disassemble | | 00:39:13 - 00:40:42 (TV) | Mark tries to apologize for telling Addison about the proposal. Derek arrives and Sam, Naomi and Addison sing his wedding song. |
| 5x16 - An Honest Mistake: |
| Matt Hires | Take Us To The Start | | 00:00:00 - 00:01:37 (TV) | At the beginning of the episode. |
| Dash And Will | | | 00:17:35 - 00:18:31 (TV) | Mark tries to tell Derek that he is dating Lexie. The residents have lunch. |
| Little Dragon | Little Dragon | | 00:27:48 - 00:32:29 (TV) | Richard stops Derek. Addison prepares to deliver the baby. Daisy Pepman examines Izzie. Addison delivers Jen's baby. Jen dies. Rob calls Derek a murderer. |
| Calahan | | | 00:38:01 - 00:39:33 (TV) | Callie interrupts Arizona's date. Addison says goodbye to Bailey. |
| Snow Patrol | A Hundred Million Suns | The Planets Bend Between Us | 00:39:33 - 00:42:16 (TV) | At the end of the episode. |
| 5x17 - I Will Follow You into the Dark: |
| Metric | | | 00:00:31 - 00:02:23 (TV) | At the beginning of the episode. |
| Rachael Yamagata | Elephants...Teeth Sinking Into Heart | | 00:28:26 - 00:32:11 (TV) | Tricia tells Meredith that her fears will save her brother's life. Izzie asks Lexie how she would present the news to Patient X. Owen and Arizona tell Alex they will talk to the Chief. Adele talks to Richard and Bailey. Alex has exciting news for Izzie. |
| Shady Bard | | | 00:33:45 - 00:36:05 (TV) | Cristina assigns herself to trauma with Owen. Richard tells Meredith something about Derek. Mark tells Lexie something nice. Arizona talks to Callie. |
| Piers Faccini | | | 00:36:57 - 00:41:36 (TV) | At the end of the episode. |
| 5x18 - Stand By Me: |
| Common | Universal Mind Control | Everywhere (ft. Martina Topley-Bird) | 00:00:00 - 00:01:38 (TV) | At the beginning of the episode. |
| Royal Wood | A Good Enough Day | | 00:33:48 - 00:36:05 (TV) | Richard convinces Derek to call Meredith. Meredith gives a "Bailey speech" to the interns. Kendall asks for a moment of Cristina's attention. Cristina tells Bailey and Alex that Izzie is sick and begins her solo surgery. |
| Great Northern | | | 00:38:32 - 00:42:08 (TV) | At the end of the episode. |
| 5x19 - Elevator Love Letter: |
| Gomez | | | 00:00:00 - 00:01:46 (TV) | At the beginning of the episode. |
| Sanders Bohlke | | | 00:16:22 - 00:19:33 (TV) | Alex shares with Meredith how frusterating the situation is. Owen has a conversation with Cristina. Bailey keeps Izzie company. Derek practices a surgery alone. |
| The Cinematic Orchestra | Ma Fleur | | 00:25:02 - 00:26:36 (TV) | Derek asks Meredith an important question. Alex arrives for Izzie but she is gone. Derek begins surgery. |
| Ben Lee | The Rebirth of Venus | | 00:30:17 - 00:32:54 (TV) | Mark calls Aunt Joyce dead. Her family says goodbye. Richard joins Meredith and the gang. Derek regains control of himself. Bailey announces to the group about Derek's success. |
| Peter Broderick | | With The Notes In My Ears | 00:33:36 - 00:36:36 (TV) | Richard comforts Derek over the two proposal failures. Alex and the gang sit with Izzie after her surgery. Cristina and Owen have sex. |
| O+S | | | 00:37:26 - 00:42:08 (TV) | At the end of the episode. |
| 5x20 - Sweet Surrender: |
| Mostar Diving Club | | | 00:00:17 - 00:02:22 (TV) | At the beginning of the episode. |
| Jont Whittington | Supernatural | | 00:30:13 - 00:33:51 (TV) | Mr Torres tells Dr Webber he'll always protect his daughter. Bailey convinces Jessica's dad to watch over Jessica, who dies in his arms. |
| Shady Bard | From the Ground Up | Summer Came When We Were Falling Out | 00:36:38 - 00:38:12 (TV) | Owen admits to Dr. Wyatt he feels shame. Derek compliments Mark in front of Dan's wife. |
| The Rescues | Crazy Ever After | | 00:39:16 - 00:41:50 (TV) | At the end of the episode. |
| 5x21 - No Good at Saying Sorry (One More Chance): |
| Emilie Mover | Good Shake, Nice Gloves | | 00:00:00 - 00:01:14 (TV) | At the beginning of the episode. |
| The Rescues | | | 00:19:26 - 00:20:19 (TV) | Meredith does not want Derek to invite Richard to the wedding. |
| Brett Dennen | Hope for the Hopeless | | 00:27:42 - 00:30:59 (TV) | Derek talks about Richard and Meredith's relationship. Meredith urges Kate to take Maddy and get away from Mike. |
| All Thieves | | | 00:33:11 - 00:38:35 (TV) | Richard apologizes to Meredith. Izzie says goodbye to Robbie. Owen explains his behavior toward Cristina. Kate and Maddy leave Mike as Meredith watches. |
| The Hard Lessons | Arms Forest | | 00:39:09 - 00:42:16 (TV) | At the end of the episode. |
| 5x22 - What a Difference a Day Makes: |
| Matthew Mayfield | | | 00:23:45 - 00:26:42 (TV) | Derek and Bailey give Izzie and EEG and wait for her to see Denny. Becca asks about her friends. Alex instead asks to hear her graduation speech. The five college kids they've lost are zipped into body bags. Meredith performs her solo surgery. |
| Au Revoir Simone | Still Night, Still Light | | 00:29:29 - 00:31:38 (TV) | Callie finally tells Arizona the truth, she's broke. Richard tells Meredith her mom would have been proud. Mer thanks Derek for her gift. Owen thanks George for his help. Alex is upset about Izzie's new tumor. |
| Ingrid Michaelson | | | 00:34:15 - 00:39:24 (TV) | Izzie, Bailey, and Mer prepare to go down the aisle. Izzie wears her wedding dress. Izzie walks down the aisle. She struggles, but George helps her. Her and Alex exchange vows. They kiss, and are married. |
| 5x23 - Here's to Future Days: |
| Joy Williams | | | 00:00:00 - 00:01:46 (TV) | At the beginning of the episode. |
| Matthew Perryman Jones | | Where The Road Meets The Sun (With Katie Herzig) | 00:31:06 - 00:35:09 (TV) | Arizona intrudes on Richard and Bailey's bonding. She invites Bailey to see joy. Chrisitna and Izzie see the terrible condition of Alison. George helps Izzie calm down and make a decision. Izzie tells Derek he can perform the surgery. |
| Sugarplum Fairies | Chinese Leftovers | | 00:38:59 - 00:42:09 (TV) | Cristina doesn't want Owen to go back. The women watch Arizona give good news to the child's parents. Owen and Cristina nervously look out the window. A clerk notifies an officer of one last thing. George makes a decision. |
| 5x24 - Now or Never: |
| Ingrid Michaelson | | | 00:00:00 - 00:01:41 (TV) | Cristina, Meredith, Alex, and George sleep in Izzie's room. Bailey checks in on them. Cristina sees Owen hug George. |
| 'Missy' Higgins | Steer | | 00:19:35 - 00:20:42 (TV) | Callie is still mad at Arizona. Derek, Callie, Owen and Mark discuss George's decision. Alex and Cristina test Izzie's memory. |
| Hollywood Mon Amour | Hollywood Mon Amour | Flashdance... What a Feeling | 00:33:18 - 00:35:30 (TV) | Meredith and Derek get married on a post-it. |
| Greg Laswell | | | 00:39:19 - 00:42:14 (TV) | At the end of the episode. |