| Artist | Album | Song Title | Start/Stop | Scene |
| 4x01 - Alone: |
| (None known) | | | | |
| 4x02 - The Right Stuff: |
| (None known) | | | | |
| 4x03 - 97 Seconds: |
| Hot Hot Heat | Happiness Ltd. | | 00:01:12 - 00:01:15 (TV) | The last song the woman turned to on the radio |
| Alanis Morissette | Flavors of Entanglement | | 00:30:11 - 00:32:03 (TV) | House thinking about electrocuting himself |
| 4x04 - Guardian Angels: |
| DJ Harry | Collision | | 00:00:00 - 00:01:50 (TV) | At the beginning of the episode |
| 4x05 - Mirror Mirror: |
| The White Stripes | White Blood Cells | We're Going To Be Friends | 00:42:05 - 00:43:09 (TV) | At the end of the episode |
| 4x06 - Whatever It Takes: |
| Linda Lyndell | | | (TV) | House's ringtone |
| My Morning Jacket | It Still Moves | | 00:00:03 - 00:01:43 (TV) | At the beginning of the episode |
| Lizz Wright | | | 00:41:51 - 00:43:15 (TV) | At the end of the episode |
| 4x07 - Ugly: |
| The Verve | A Storm in Heaven | | 00:00:38 - 00:01:23 (TV) | At the beginning of the episode |
| Joseph Arthur | And the Thieves are Gone | | 00:35:13 - 00:36:15 (TV) | Kenny on his way to the surgery |
| 4x08 - You Don't Want to Know: |
| (None known) | | | | |
| 4x09 - Games: *(Additional music info in episode details) |
| Alan Milman Sect + Man-Ka-Zam | Stitches | | 00:00:00 - 00:01:33 (TV) | At the beginning of the episode |
| Pussy Galore | Dial 'M' for Motherfucker | | 00:16:34 - 00:16:59 (TV) | House plays this first to Wilson |
| Pussy Galore | Dial 'M' for Motherfucker | | 00:33:04 - 00:33:41 (TV) | Then plays this in his office |
| Pussy Galore | Dial 'M' for Motherfucker | | 00:38:08 - 00:38:49 (TV) | And again, House plays this to Quidd to give him a seizure |
| Norman Greenbaum | Spirit in the Sky | | 00:42:35 - 00:43:13 (TV) | At the end of the episode |
| 4x10 - It's a Wonderful Lie: *(Additional music info in episode details) |
| Frank Sinatra | The Stars Come Out For Christmas | Hark! The Herald Angels Sing | 00:05:41 - 00:06:41 (TV) | House talking to Wilson about lies |
| Felix Gross | Savoy Christmas Blues | | 00:09:47 - 00:10:01 (TV) | Cuddy asking House for money for the nurses' bonuses |
| Jimmy Butler | | | 00:25:59 - 00:26:16 (TV) | Kutner giving House a present |
| The Fab Four | | | 00:32:34 - 00:33:16 (TV) | The team discussing giving House presents |
| Roy Hargrove | | God Rest Ye Merry Gentlemen | 00:36:07 - 00:37:50 (TV) | House talking to Wilson at the Christmas party |
| The Ramsey Lewis Trio | Sound Of Christmas | Santa Claus Is Coming To Town | 00:40:18 - 00:41:56 (TV) | House's old and new team getting together at the party |
| The Staple Singers | We'll Get Over | Who Took The Merry Out Of Christmas? | 00:41:59 - 00:43:11 (TV) | At the end of the episode |
| 4x11 - Frozen: |
| Marvin Gaye | Let's Get It On | | 00:20:11 - 00:20:51 (TV) | House watching Cate's check her lymph nodes |
| Civil Twilight | Human | | 00:40:06 - 00:41:22 (TV) | Sean putting Cate's toe right |
| Mungal | | | 00:41:22 - 00:42:42 (TV) | House talking to Wilson at the restaurant (Mungal & Nitin Sawhney) |
| 4x12 - Don't Ever Change: *(Additional music info in episode details) |
| Richard Kaplan | Life of the Worlds: Journeys in Jewish Sacred Music | Niggun of the Alter Rebbe | 00:00:00 - 00:00:31 (TV) | At the beginning of the episode |
| Waldeck | Ballroom Stories | | 00:14:32 - 00:16:13 (TV) | House crashing Amber's and Wilson's date |
| Accentus Ensemble | Sephardic Romances | | 00:34:46 - 00:35:16 (TV) | The team faking sunset |
| The Rolling Stones | Tattoo You | | 00:41:28 - 00:43:13 (TV) | At the end of the episode |
| 4x13 - No More Mr. Nice Guy: *(Additional music info in episode details) |
| Kristen Mari | N My Shoes | | 00:05:35 - 00:06:11 (TV) | First song at the bowling alley |
| Sly & The Family Stone | Greatest Hits | | 00:06:14 - 00:07:56 (TV) | Second song at the bowling alley |
| The Supremes | | | 00:42:00 - 00:43:00 (TV) | At the end of the episode. |
| 4x14 - Living the Dream: |
| The Beta Band | The Three E.P.'s | | 00:37:32 - 00:38:37 (TV) | Waiting for the result of the tests while House started treatment. |
| 4x15 - House's Head: |
| Chingy | Hoodstar | | 00:00:00 - 00:02:41 (TV) | At the beginning of the episode |
| !!! | !!! Chk Chik Chick | There's No Fucking Rules, Dude | 00:22:03 - 00:23:16 (TV) | Cuddy giving House a striptease |
| 4x16 - Wilson's Heart: |
| José González | In Our Nature | | 00:20:56 - 00:22:06 (TV) | Playing right before Wilson discovers that Foreman and Cuddy are elevating Amber's temperature |
| Bon Iver | For Emma, Forever Ago | | 00:35:41 - 00:37:00 (TV) | Saying goodbye to Amber |
| People in Planes | As Far as the Eye Can See | | 00:38:06 - 00:38:49 (TV) | House meeting Amber in the bus |
| Iron & Wine | Our Endless Numbered Days | | 00:40:20 - 00:43:13 (TV) | At the end of the episode |