| Artist | Album | Song Title | Start/Stop | Scene |
| 1x01 - Pilot: |
| Cooler Kids | Punk Debutante | All Around the World (Punk Debutante) | | The fashion show benefit |
| Black Eyed Peas | Elephunk | | | Seth and Ryan arriving at the party |
| Joseph Arthur | Redemption's Son | | | Ryan brought back home |
| The K.G.B. | The K.G.B. | | | Seth mistaking Ryan for flirting with Summer |
| Mazzy Star | So Tonight That I Might See | | | Ryan bringing Marissa back to the poolhouse |
| Maximum Roach | | | | Seth and Ryan fight the on the beach |
| Cham Pain | | | | Luke picking up Marissa |
| Slightly Stoopid | Everything You Need | | | Ryan and Seth hittin' the high sea in Seth's boat |
| The All American Rejects | The All-American Rejects | | | On their way to the after-party |
| 1x02 - The Model Home: |
| Rufus Wainwright | Poses | | | Opening scenary scene |
| Doves | The Last Broadcast | | | Seth, Ryan and Marissa down at the pier |
| The Androids | The Androids | | | Summer and Marissa talking at the party |
| Jeff Buckley | Grace | | | Marissa asking Ryan if she can stay the night |
| Rooney | Rooney | | | Playing in Marissa's car on her way to the home |
| Aaron D | | | | Seth talking after the fight in the restaurant |
| Shady Lady | | | | Summer talking to Luke at the party |
| 1x03 - The Gamble: |
| Turin Brakes | Ether Song | | | Kristin and Dawn talking about Ryan and when Dawn decides to leave and waves goodbye to Ryan |
| James Horner | Swing Kids OST | Sing, Sing, Sing (With A Swing), | | Ryan trying to keep an eye on his mom |
| Brooke | Coming Home | | | Marissa and Summer talking about Ryan and Luke |
| 1x04 - The Debut: |
| Leona Naess | Comatised | | | Ryan telling Marissa he’s not going and helping her do up her dress |
| Brassy | Got It Made | | | The song playing at Holly's beach house party |
| Smashing Pumpkins | Adore | | | Ryan finds Marissa sitting outside crying |
| Liz Phair | Liz Phair | | | Summer and Marissa talking about Ryan in dressing room |
| 1x05 - The Outsider: |
| Fountains of Wayne | Welcome Interstate Managers | | | Ryan and Marissa swimming |
| grade 8 | grade 8 | | | Seth and Ryan leaving the party |
| The Grand Skeem | | | | |
| Black Eyed Peas | Elephunk | | | When Ryan and Seth first get to the party and when the dancer Seth liked is dancing |
| The Grand Skeem | The Grand Skeem | | | |
| The Roots | Phrenology | | | Playing at Holly's house party |
| The Grand Skeem | | | | |
| Spoon | Kill the Moonlight | | | Ryan on his bike and Seth skateboarding to a lobster resturant |
| 1x06 - The Girlfriend: |
| Soul Kid #1 | Americanized | (More Bounce In) California | | Ryan riding his bike and Seth skateboarding and they see Summer and Marissa |
| Palm Street | | | | |
| The Faders | | | | |
| User | | | | |
| Tricky | Vulnerable | | | Marissa and Luke getting ready to do it |
| The Runaways | Waitin' for the Night | | | Playing in Marissa's room when Luke walks in |
| OK Go | OK Go | | | Gabrielle getting out of the pool |
| 1x07 - The Escape: |
| Death Cab for Cutie | The Photo Album | | | Plays in the car while driving to Tijuana |
| Rockers Hi-Fi | Mish Mash | | | Marissa going to the bar and taking the pills (Kruder & Dorfmeister Remix) |
| Mazzy Star | So Tonight That I Might See | | | Ryan, Seth and Summer finding Marissa in the alley |
| Los Cubaztecas | | | | |
| The Chemical Brothers | Surrender | | | Plays in the bar that Ryan, Seth, Summer and Marissa go to in Tijuana |
| Los Cubaztecas | | | | |
| 1x08 - The Rescue: |
| Guster | Keep It Together | | | At the end of the episode |
| Air | Moon Safari | | | |
| Paul Westerberg | Stereo | | | |
| 1x09 - The Heights: |
| Solomon Burke | Don't Give Up on Me | | | |
| The 88 | Kind of Light | | | |
| South | From Here On In | | | |
| 1x10 - The Perfect Couple: |
| Stacey Kent | Let Yourself Go: Celebrating Fred Astaire | | | Seth and Anna sharing a romantic moment on a yacht |
| Leaves | Breathe | | | Ryan and Marissa sharing a tender moment in the pool room |
| Aqualung | Strange and Beautiful | Strange And Beautiful (I'll Put A Spell On You) | | Ryan and Marissa makeing out in the pool room |
| 1x11 - The Homecoming: |
| Minibar | Fly Below the Radar | | | Ryan and Marissa making out in the pool room and then talk about Ryan's brother |
| The John Buzon Trio | | | | Seth and Summer kissing |
| Gordon Jenkins | | | | Seth and Anna kissing |
| Trespassers William | Different Stars | | | Ryan visiting his brother in prison |
| Mellow Man Ace | Vengo a Cobrar | | | Ryan talking to Gattas |
| Alexi Murdoch | Time Without Consequence | | | Ryan visiting his brother in prison who tells him to leave the past behind and work towards the future |
| Earlimart | Everyone Down Here | | | Seth and Ryan looking at comic books in Seth's room |
| 1x12 - The Secret: |
| Jet | Get Born | | | Playing on the car radio before Luke and Ryan see Luke’s dad with another man |
| Belle & Sebastian | Dear Catastrophe Waitress | | | Julie and Kirsten talking in the Mexican restaurant |
| Jet | Get Born | | | Seth, Luke, Ryan, and Marissa facing the day at school |
| The Dandy Warhols | Welcome To The Monkey House | | | First in the teaser as Seth feigns illness and Ryan busts him, then when Seth runs into Summer and Anna and they get their revenge, and when Summer and Anna sit with each other and bond |
| 1x13 - The Best Chrismukkah Ever: |
| The Dandy Warhols | Welcome To The Monkey House | | | In the kitchen as Seth talks to Kirsten, in Jimmy’s apartment as he talks with Julie, in a bathroom stall as Marissa drinks alcohol, in a therapist’s waiting room as Marissa waits for her appointment |
| Bright Eyes | | | | Ryan hanging his stocking on the fireplace while he's talking to Seth |
| FirstCom Music | | | | |
| Ron Sexsmith | A Winter's Night | | | Ryan and Marissa shop at a high end department store |
| Eartha Kitt | Elf | | | Summer giving Seth his Christmas present |
| The Ventures | The Ventures' Christmas Album | Santa Claus is Coming to Town | | Seth introducing Ryan to the concept of "Chrismukkah" |
| FirstCom Music | | | | |
| FirstCom Music | | We Wish You a Merry Christmas | | |
| Peggy Lee | Christmas Cocktails | | | The Cohen's attenting a fancy Christmas party |
| 1x14 - The Countdown: |
| Zero 7 | Simple Things | | | Playing at a party in Laguna Beach (Photec Remix) |
| Finley Quaye | Much More Than Much Love | | | Ryan finding Marissa at a New Year’s Eve party and kissing her (Finley Quaye & Beth Orton) |
| The Suicide Machines | A Match and Some Gasoline | Did You Ever Get A Feeling of Dread? | | Also playing at the Cohen house party |
| The Flaming Sideburns | Save Rock 'n' Roll | | | Also playing at the Four Seasons penthouse party |
| Jem | Finally Woken | | | Also playing at a party in Laguna Beach |
| The Vacation | The Vacation | | | Playing at the Cohen house party |
| Singapore Sling | The Curse of the Singapore Sling | | | Playing at the Four Seasons penthouse party |
| Laptop | Don't Try This at Home | | | Also when Ryan and Seth trapped in the poolhouse together |
| The Pattern | Real Feelness | | | The Cohens preparing for the party |
| Dropkick Murphys | Blackout | | | Ryan and Seth trapped in the poolhouse together |
| Brookville | Wonderfully Nothing | | | Kirsten and Sandy talking about their marriage in his car |
| Alkaline Trio | Good Mourning | | | Ryan weaving his way through the crowd at the house party |
| 1x15 - The Third Wheel: |
| Rooney | Rooney | | | The gang listening to the Rooney album before going to their concert |
| Ash | Free All Angels | | | Playing at a concert venue after the band has finished their set |
| Rooney | Rooney | | | The band performing |
| Rooney | Rooney | | | The band performing |
| Beulah | The Coast Is Never Clear | Popular Mechanics For Lovers | | Marissa & Ryan and Anna & Seth talk at school |
| Eels | Shootenanny! | | | Everyone is getting ready to leave in the kitchen |
| Buva | | | | Playing at a concert while the crowd waits for the band to go on |
| Rooney | Rooney | | | Playing on the radio resulting in the the gang to talk about the upcoming Rooney show |
| Laptop | Don't Try This at Home | | | The group arriving at a club to see a concert |
| 1x16 - The Links: |
| Enrique Iglesias | 7 | | | Playing as Summer interrupts Anna and Seth’s quiet time and turns on the TV |
| Puddle of Mudd | Life on Display | | | Sandy trying to teach Ryan how to golf, the group gathering for a road trip, Oliver racing Ryan in their golfcarts, Ryan and Seth talking to Kirsten about their weekend |
| Tom Jones | Reloaded: Greatest Hits | | | Playing over an establishing shot of Palm Springs and in a Palm Springs hotel room as the gang arrives; Oliver dancing around the hotel room opening bottles of pills |
| Martin Denny | The Exciting Sounds of Martin Denny: Exotica | | | Playing as Summer interrupts Anna and Seth’s quiet time and turns on the TV; Playing as Anna and Seth kiss on the bed in their hotel room before Seth yawns in her face |
| Martin Denny | Greatest Hits | | | Seth and Anna playing Jenga in their hotel room |
| 1x17 - The Rivals: |
| The Thrills | So Much for the City | | | Oliver taunting Ryan about stealing Marissa from him before Ryan punches him |
| Mosquitos | Mosquitos | | | Seth encounters Danny |
| Damien Rice | O | | | Summer and Seth talking in the hallway about Danny |
| Clinic | Walking with Thee | | | Playing as Ryan catches up to Marissa in the hallway, in the Cohen house, continues as Ryan sneaks onto the school campus, as Ryan watches Oliver give Marissa a letter and as Ryan reads the letter Oliver wrote to Marissa |
| The New Amsterdams | Worse for the Wear | The Spoils Of The Spoiled | | Seth and Ryan talking about Olivers letter in Seth's room |
| 1x18 - The Truth: |
| I am Kloot | I am Kloot | | | Playing in the Lounge at Harbor High |
| Eels | Shootenanny! | | | Ryan wasting time before school, watching TV and fighting with Seth |
| Azure Ray | Hold on Love | | | Ryan talking to Julie about Marissa and Marissa and Oliver talking |
| Turin Brakes | Ether Song | | | Seth apologizing for not having Ryan's back |
| MasterSource Music | | Watching The Game At Joe's | | |
| 1x19 - The Heartbreak: |
| Squirrel Nut Zippers | The Inevitable | | | Playing at the Valentine’s Day Dance |
| Mojave 3 | Spoon and Rafter | | | Seth telling Ryan that he lost his virginity |
| MasterSource Music | | | | |
| Super Furry Animals | Phantom Power | | | Summer and Seth getting physical in her room |
| Bob Seger | Greatest Hits | | | Luke showing up at Julie’s door to tell her his feelings (Bob Seger & the Silver Bullet Band) |
| The Fire Theft | The Fire Theft | | | Ryan and Luke helping to set up an event at the Cicada ballroom |
| Ryan Adams | Love Is Hell | | | Seth dancing with Summer on Valentine’s Day and Ryan and Marissa deciding the future of their relationship |
| 1x20 - The Telenovela: |
| Mojave 3 | Spoon and Rafter | | | Ryan walking with Theresa on the beach, Marissa discussing Ryan with Theresa, and Ryan and Theresa further complicating their relationship/friendship with a kiss |
| Preston School Of Industry | Monsoon | | | Ryan and Seth walking across the campus and talking about Ryan and Marissa’s relationship |
| Halloween, Alaska | Halloween, Alaska | | | Ryan coming home to find Eddie looking for Theresa and when Ryan talks to Eddie about Theresa, and Marissa listens to Theresa discuss her relationship with Eddie |
| James William Hindle | Prospect Park | | | Ryan and Marissa having an awkward conversation about Theresa in the school cafeteria |
| Patrick Park | Loneliness Knows My Name | | | Seth interrupting Summer's involvement at the school kissing booth |
| 1x21 - The Goodbye Girl: |
| Death Cab for Cutie | Transatlanticism | | | Seth talking to Anna in the hallway about her decision to move back east |
| Trespassers William | Different Stars | | | Ryan and Theresa browsing the classified ads |
| Nada Surf | Music from The O.C.: Mix 2 | | | Seth droping off Anna at the airport and saying goodbye |
| Journey | Frontiers | Separate Ways (Worlds Apart) | | Ryan and Seth trying to get to the airport before Anna’s plane leaves |
| MasterSource Music | | | | |
| Interpol | Matador at Fifteen | | | Ryan showing up at Theresa's hotel room to talk and them ending up hooking up |
| MasterSource Music | | | | |
| 1x22 - The L.A.: |
| The Plus Ones | It's a Calling | | | Playing when an actor puts "his band" on the radio to impress Summer |
| The Crystal Method | Legion of Boom | | | Playing when the gang walks into a "Hollywood" club |
| Kid Gloves Music | | | | |
| K-Dub | | | | Playing at the Luna-Chicks VIP entrance |
| The 88 | Kind of Light | | | The gang being stuck in L.A. traffic |
| Jude | No One Is Really Beautiful | | | The gang winding down their crazy night out in L.A. |
| The Vines | Winning Days | | | Seth and Ryan seeing Luke leaving a hotel with a woman |
| Radio 4 | Gotham! | | | Playing in a "Hollywood" club as Ryan catches Hailey dancing and Summer is hit on by an actor |
| Secret Machines | Now Here Is Nowhere | The Road Leads Where It's Led | | Playing when Ryan discovers Hailey is a stripper at an L.A. club |
| Timo Maas | Loud | | | Playing in a "Hollywood" club when Seth catches Hailey working as a dancer |
| 1x23 - The Nana: |
| Modest Mouse | Good News For People Who Love Bad News | | | Ryan and Marissa at the engagement party in Chino |
| Chris Murray | One Everything | | | Ryan and Marissa talking at the backyard barbecue |
| Jem | Finally Woken | | | Jimmy checking up on Hailey and flirting with each other |
| Aqualung | Still Life | | | Ryan and Marissa returning from Chino |
| 1x24 - The Proposal: *(Additional music info in episode details) |
| Christina Lux | Believe | | | Seth and Summer looking through an old yearbook and when Marissa and Ryan say goodbye to Luke |
| Henry Mancini | Breakfast At Tiffany's OST | | | Luke watching people go in |
| Bob Seger | Greatest Hits | | | Luke being really depressed, blowing Ryan off and calling Julie (Bob Seger & the Silver Bullet Band) |
| Aidan Hawken | Pillows & Records | | | Marissa seeing her redecorated room |
| Syntax | Meccano Mind | | | Marissa being upset about Luke and Julie |
| 1x25 - The Shower: |
| Camera Obscura | Underachievers Please Try Harder | | | Seth and Summer talking about meeting her father |
| Zack Hexum | The Story So Far... | | | Ryan and Marissa talking in the student lounge |
| South | With the Tides | | | Ryan and Marissa sitting together quietly in the backyard |
| Mocean Worker | Enter the Mowo! | | | Playing at the Country Club during Julie's shower |
| 1x26 - The Strip: |
| Beastie Boys | To The 5 Boroughs | | | The guys arriving to the Hard Rock Casino on the strip |
| Ohio Players | Fire | | | The firemen beginning their show at Julie's party |
| Tricky | Vulnerable | | | Jenn taking Ryan and Seth to a $250 buy in poker game |
| Franz Ferdinand | Franz Ferdinand | | | Kristin asking for Hailey to help her find a stripper for Julie's bachelorette party and when Ryan and Seth encounter a hot young coed named Jenn |
| The Willowz | Are Coming | | | Julie fighting with Hailey |
| Electrelane | The Power Out | | | Seth and Marissa offering Ryan money to help Theresa out |
| Zero 7 | When It Falls | | | Summer arriving at the Hard Rock in Vegas to find Seth up in the penthouse kissing Jenn |
| Johnathan Rice | Trouble Is Real | | | Sandy questioning Caleb about the Lighthouse |
| STARS | Heart | | | Playing at Julie's bachelorette party when Hailey arrives with firemen |
| 1x27 - The Ties That Bind: |
| CAR 188 | | | | Playing in the background of the wedding ceremony |
| Jem | Finally Woken | | | Ryan and Marisa walking together when Ryan wants to make it work between them |
| Jeff Buckley | Grace | | | At the end of the episode |
| APM Music | | | | Julie entering the chapel and walking down the aisle |
| Jem | Music from the O.C.: Mix 2 | | | Jem sings the song at the reception while everybody dances on the dancefloor |
| Alexi Murdoch | Time Without Consequence | | | Ryan and Marisa eating lunch together at school |
| Iron & Wine | The Sea & The Rhythm EP | | | Ryan, Marisa, Seth and Summer walking along the beach and remembering the beginning of the year |