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Guide available in: 
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Choose Season: 1 | 12 | 13 | 14 | 15 | 16 | 19 | 20 | 21 | 22 | All Seasons |
| # | Ep. No. | Episode Title | Prod # | Available Info | iTunes DL | Broadcast | Comments |
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| 1137 | 21x01 | Oprah & Gayle's Big Adventure: Part 1 | | |edit | | 2006-09-18 | Discuss episode! |
| 1138 | 21x02 | Jim McGreevey, His Gay Sex Scandal | | |edit | | 2006-09-19 | Discuss episode! |
| 1139 | 21x03 | Matthew McConaughey, Eva Longoria, Bon Jovi | | C |edit | | 2006-09-20 | Discuss episode! |
| 1140 | 21x04 | What's the Buzz? Salma Hayek, Forest Whitaker and John Legend | | |edit | | 2006-09-21 | Discuss episode! |
| 1141 | 21x05 | Oprah's Most Burning Questions | | |edit | | 2006-09-22 | Discuss episode! |
| 1142 | 21x06 | Janet Jackson | | |edit | | 2006-09-25 | Discuss episode! |
| 1143 | 21x07 | Oprah & Gayle's Big Adventure: Part 2 | | |edit | | 2006-09-26 | Discuss episode! |
| 1144 | 21x08 | The Day Your World Falls Apart: Elizabeth Edwards | | |edit | | 2006-09-27 | Discuss episode! |
| 1145 | 21x09 | What Pedophiles Don't Want You To Know | | |edit | | 2006-09-28 | Discuss episode! |
| 1146 | 21x10 | Annette Bening, Morgan Freeman | | C |edit | | 2006-09-29 | Discuss episode! |
| 1147 | 21x11 | Wives Confess They Are Gay | | |edit | | 2006-10-02 | Discuss episode! |
| 1148 | 21x12 | Oprah & Gayle's Big Adventure: Part 3 | | |edit | | 2006-10-03 | Discuss episode! |
| 1149 | 21x13 | Back From The Brink Of Suicide | | |edit | | 2006-10-04 | Discuss episode! |
| 1150 | 21x14 | Great Women On Getting Older | | |edit | | 2006-10-05 | Discuss episode! |
| 1151 | 21x15 | Truth In America -- The Darfur Crisis | | |edit | | 2006-10-06 | Discuss episode! |
| 1152 | 21x16 | Dr. Oz Answers Your Most Embarrassing Questions | | |edit | | 2006-10-09 | Discuss episode! |
| 1153 | 21x17 | Oprah and Gayle's Big Adventure: Part 4 | | |edit | | 2006-10-10 | Discuss episode! |
| 1154 | 21x18 | Lisa Ling Takes A Rare Trip Inside North Korea | | |edit | | 2006-10-11 | Discuss episode! |
| 1155 | 21x19 | Truth In America | | |edit | | 2006-10-12 | Discuss episode! |
| 1156 | 21x20 | Bono's Red Campaign | | |edit | | 2006-10-13 | Discuss episode! |
| 1157 | 21x21 | Jennifer Aniston's New Passion | | C |edit | | 2006-10-16 | Discuss episode! |
| 1158 | 21x22 | Oprah and Gayle's Big Adventure: Part 5 | | |edit | | 2006-10-17 | Discuss episode! |
| 1159 | 21x23 | Barack Obama On the Tough Questions | | |edit | | 2006-10-18 | Discuss episode! |
| 1160 | 21x24 | The Mom Afraid to Touch Her Own Children | | |edit | | 2006-10-19 | Discuss episode! |
| 1161 | 21x25 | Childhood Interupted | | |edit | | 2006-10-20 | Discuss episode! |
| 1162 | 21x26 | Moms Around The World | | |edit | | 2006-10-23 | Discuss episode! |
| 1163 | 21x27 | Suddenly Skinny | | |edit | | 2006-10-24 | Discuss episode! |
| 1164 | 21x28 | Madonna & The Dixie Chicks Speak Out | | C |edit | | 2006-10-25 | Discuss episode! |
| 1165 | 21x29 | NBA Legend Magic Johnson On AIDS in America | | |edit | | 2006-10-26 | Discuss episode! |
| 1166 | 21x30 | Oprah's Town Hall with Bill O'Reilly | | C |edit | | 2006-10-27 | Discuss episode! |
| 1167 | 21x31 | Oprah's Favorite Giveaway Ever! | | |edit | | 2006-10-30 | Discuss episode! |
| 1168 | 21x32 | Denzel Washington | | C |edit | | 2006-10-31 | Discuss episode! |
| 1169 | 21x33 | The Best Pizza In America | | |edit | | 2006-11-01 | Discuss episode! |
| 1170 | 21x34 | The Dr. Oz Diet | | |edit | | 2006-11-02 | Discuss episode! |
| 1171 | 21x35 | Why 15-Year-Old Jessica Coleman Killed Her Baby | | |edit | | 2006-11-03 | Discuss episode! |
| 1172 | 21x36 | Kirstie Alley's Bikini Reveal | | |edit | | 2006-11-06 | Discuss episode! |
| 1173 | 21x37 | Dreams Come True With Emilio Estevez & Lindsay Lohan | | C |edit | | 2006-11-07 | Discuss episode! |
| 1174 | 21x38 | Confronting the Attacker | | |edit | | 2006-11-08 | Discuss episode! |
| 1175 | 21x39 | Oprah's High School Challenge | | |edit | | 2006-11-09 | Discuss episode! |
| 1176 | 21x40 | Headline Making Survivors | | |edit | | 2006-11-10 | Discuss episode! |
| 1177 | 21x41 | The Secret Language Of Babies | | |edit | | 2006-11-13 | Discuss episode! |
| 1178 | 21x42 | Dad Kills Twins: The Truth About Depression | | |edit | | 2006-11-14 | Discuss episode! |
| 1179 | 21x43 | Inside the $75 Million House | | |edit | | 2006-11-15 | Discuss episode! |
| 1180 | 21x44 | Dream Jobs: Behind the Scenes with Oprah at Work | | |edit | | 2006-11-16 | Discuss episode! |
| 1181 | 21x45 | On Location: Oprah on the Set of "Grey's Anatomy" | | |edit | | 2006-11-17 | Discuss episode! |
| 1182 | 21x46 | Beyonce, Jamie Foxx, & Eddie Murphy | | C |edit | | 2006-11-20 | Discuss episode! |
| 1183 | 21x47 | Nate's $10,000 Challenge | | |edit | | 2006-11-21 | Discuss episode! |
| 1184 | 21x48 | Season 23, Episode 48 | | |edit | | 2006-11-22 | Discuss episode! |
| 1185 | 21x49 | Season 23, Episode 49 | | |edit | | 2006-11-23 | Discuss episode! |
| 1186 | 21x50 | Season 23, Episode 50 | | |edit | | 2006-11-24 | Discuss episode! |
| 1187 | 21x51 | Season 23, Episode 51 | | |edit | | 2006-11-27 | Discuss episode! |
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Choose Season: 1 | 12 | 13 | 14 | 15 | 16 | 19 | 20 | 21 | 22 | All Seasons
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General Info:
Click on the episode names to get more information about them. |
Legend:
P Plot Outline present.
D Director of episode present.
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W Writer of episode present.
C Cast information available.
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M Music information present.
N Additional Notes present.
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